There’s one U.S. company developing a novel-coronavirus vaccine candidate that’s probably been in the headlines more than any other. Moderna (NASDAQ:MRNA) made waves earlier this year with its rapid development of a COVID-19 vaccine candidate that uses messenger RNA (mRNA). The mRNA spurs the ribosomes to generate antigens that are like the spike protein in SARS-CoV-2 (the novel coronavirus), then the body responds by producing antibodies against it.

Moderna quickly established itself as a leader in the race to develop a COVID-19 vaccine. Its stock has skyrocketed as a result, more than quadrupling so far this year.

But a much larger drugmaker also has a mRNA-based COVID-19 vaccine candidate. Pfizer (NYSE:PFE) teamed up with German biotech BioNTech (NASDAQ:BNTX) in March because of the promise of its BNT162 program. Don’t be surprised if Pfizer actually becomes a bigger coronavirus winner than Moderna.

Image source: Getty Images.

Running neck-and-neck

One reason why Moderna has received so much attention is that its COVID-19 vaccine candidate, mRNA-1273, advanced through clinical studies very quickly. A phase 1 study conducted by the National Institutes of Health dosed its first participant on March 16. Moderna’s phase 2 study of mRNA-1273 began in late May. The biotech kicked off a phase 3 study earlier this week.

Pfizer and BioNTech were over a month behind Moderna in beginning clinical testing of four COVID-19 vaccine candidates, with the first participants in a phase 1/2 study conducted in Germany dosed on April 29. A phase 1/2 study in the U.S. began the following week.

But Pfizer has now nearly caught up with Moderna. The big drugmaker and its smaller German partner announced on Tuesday of this week that COVID-19 vaccine candidate BNT162b2 is being advanced into pivotal phase 2/3 clinical testing.

More importantly, Pfizer and BioNTech could have late-stage results roughly around the same time as Moderna. The two companies stated that they “expect to be ready to seek Emergency Use Authorization or some form of regulatory approval as early as October 2020.” That’s in line with public statements made by Moderna CEO Stephane Bancel, who recently said that late-stage results for mRNA-1273 could be released in October or November.

Way ahead

Pfizer is way ahead of Moderna in other ways.

Moderna is on track to be able to make around 500 million doses of its COVID-19 vaccine annually beginning in 2021. It thinks that this level could be increased to 1 billion doses per year, but Moderna is relying on third parties to help boost its production capacity.

Meanwhile, Pfizer and BioNTech expect to deliver up to 100 million doses by the end of this year, assuming BNT162b2 wins authorization or approval. The companies aim to produce around 1.3 billion doses by the end of 2021.

So far, Moderna has received substantial funding from the U.S. government. However, the biotech has not yet lined up any supply deals in the U.S., or with any other country.

What about Pfizer? It recently landed a massive deal with the U.S. government to supply an initial order of 100 million doses of its COVID-19 vaccine for $1.95 billion. There’s also an option in the agreement for the U.S. to purchase another 500 million doses.

In addition, Pfizer signed a deal with the United Kingdom to supply 30 million doses of its COVID-19 vaccine for an undisclosed amount. Both the U.S. and U.K. agreements are contingent upon approval or authorization of the coronavirus vaccine developed by Pfizer and BioNTech.

Different kinds of winning

It’s not hard to imagine Pfizer becoming a bigger winner with BNT162b2 than Moderna will be with mRNA-1273. Pfizer’s greater production capacity and big supply agreements already in place give it distinct advantages. There’s also a possibility that BNT162b2 could have a better safety profile than mRNA-1273, although we won’t know for sure until late-stage results are available for both vaccine candidates.

However, there are different kinds of winning. Even if BNT162b2 is more successful commercially than mRNA-1273 (again, assuming both vaccine candidates win approval), Moderna could still beat Pfizer in terms of stock performance. A biotech stock like Moderna, with a market cap of around $32 billion, would have much more room to run than a big pharma stock like Pfizer, with a market cap of close to $220 billion.

Also keep in mind that Moderna owns all the rights to mRNA-1273. Pfizer gave BioNTech an upfront payment of $185 million and made an equity investment of around $113 million in the German biotech. It might have to pay BioNTech up to $563 million in milestone payments. Details of how any sales and profits of BNT162b2 would be split between the two partners weren’t announced. The bottom line is that Pfizer won’t pocket all of the money that BNT162b2 might make if it’s approved.

Even with these caveats, though, Pfizer should stand to make a lot of money if BNT162b2 is successful in late-stage testing. And with a merger of its growth-challenged Upjohn unit with Mylan likely to wrap up in the fourth quarter of 2020, the big drugmaker could soon become a bigger winner than it’s been in a long time.

• The four big tech giants announced blockbuster earnings on Thursday, just a day after testifying before the Congress on anticompetitive behaviour.
• Facebook, Amazon, Google, and Apple added an additional $230 billion in market value.
• Analysts warn that while there may be tougher times ahead for these companies, their business is far from reaching its peak. 
• Visit Business Insider’s homepage for more stories.

Four of the biggest tech companies in the world – Amazon, Apple, Google, and Facebook – announced stronger-than-expected second-quarter earnings on Thursday, defying worries about Wednesday’s antitrust hearings and an ongoing pandemic. 

The strong results from the four companies, often categorized as “Big Tech,” comes a day after their CEOs testified before the Congress, defending the size of their companies

Amazon CEO Jeff Bezos, Facebook CEO Mark Zuckerberg, Alphabet CEO Sundar Pichai and Apple CEO Tim Cook took part in an ongoing investigation by the House Judiciary’s antitrust subcommittee that looked into whether the big tech companies are using their position to control the market unfairly. 

It also comes at a time when the world is in the midst of containing a pandemic and the economic blowout is visible across sectors and the economy. On Thursday, the US gross domestic product fell at an annualized rate of 33% in the second quarter, the Commerce Department said Thursday. It’s the largest fall on record dating back to the 1940s. 

On Friday, the euro zone economy shrank at its fastest rate in history, losing 12.1% in the second-quarter. 

How big is Big Tech?

However, the pandemic seems to have helped Big Tech add another $230 billion of market value. With more people staying home during lockdown, there has been a surge in demand and usage.

On Wednesday, Facebook founder Mark Zuckerberg implied at the historic antitrust hearing that every other company was beating the social media giant.

“The most popular messaging service in the US is iMessage,” Zuckerberg said in his opening remarks, referring to Apple’s texting service. “The fastest-growing app is TikTok. The most popular app for video is YouTube. The fastest growing ads platform is Amazon. The largest ads platform is Google. And for every dollar spent on advertising in the US, less than 10 cents is spent with us.”

Yet on Thursday, Facebook’s earnings jumped 11% year-on-year. It reported daily active users of nearly 1.8 billion, 12% higher than last year, and monthly active users of 2.7 billion, another 12% rise.

This contrast — a Big Tech CEO playing down their size one day and revealing impressive earnings the next — was replicated across Amazon, Apple, and Alphabet, Google’s parent company. In Congress, these companies portrayed themselves as plucky success stories that faced fierce competition. Their balance sheets tell a different story.

Amazon reported record quarterly profit and a 40% bump in sales. In his opening remarks to Congress on Wednesday, Bezos had argued: “Every day, Amazon competes against large, established players like Target, Costco, Kroger, and, of course, Walmart—a company more than twice Amazon’s size.” This week, Bezos’ net worth has increased to $181 billion thanks to the rise in Amazon’s share price.

Apple reported Q3 revenues of $59.7 billion, more than $6 billion up on last year, and profits of $11.25 billion despite shuttering many of its stores.

Alphabet was the only one of the four to see revenue decline to $31.6 billion, down 2% year-on-year as advertising demand slowed, but it still beat Wall Street estimates.

Christopher Rossbach, CIO of J. Stern & Co., said in a research note that the antitrust hearings may mean some tough times ahead but these companies continue to grow. “Tougher times may lie ahead, and investors need to be aware that — as we have seen with the Congressional Hearing this week — politicians are growing increasingly concerned about the reach of these companies. But that doesn’t mean the business has peaked, indeed far from it.

On Amazon, Rossbach said, “We expect that more people will use ecommerce in future as habits will form, while Amazon has many more areas of retail spend to expand into. For example, just this week, Amazon announced a new service for the UK grocery sector which has seen online food delivery almost double over the last four months during the pandemic. In the US, with its large and loyal Amazon Prime membership base, Amazon can capture even more share than the estimated 4% that they currently have in US retail spend — we expect it to double in the next decade,” J.Stern & Co.’s Rossbach said. 

Meanwhile, Martin Garner, COO at CIS Insight said in a note that Facebook was insulated from the worst of the COVID-19 affects because smaller companies needed to move online quickly in order to reinvent themselves during the lockdown.

“Facebook saw healthy growth in user numbers, with those using any of the Facebook family of services in a month passing 3 billion for the first time during 2Q20. This extraordinary reach plus its strength in direct response advertising meant that Facebook saw less of a hit on its advertising business than others. These also helped increase the number of active advertisers on the platform to 9 million.”

Apple has a similar story to tell. The iPhone maker beat analyst expectations with its stock price crossing $400 per share for the first time on Thursday. 

“COVID-19 has demonstrated that Apple is a more diversified and resilient business than many gave them credit for. The unique dynamics of the pandemic saw the usual growth dynamics reverse with Mac and iPad flying high whilst iPhone and Watch slowed. Meanwhile, services has become the recurring revenue stream that delivers with remarkable consistency,” Geoff Blaber, Vice President Research at CCS Insight said in a note.

Market Performance

The stellar performance from the tech giants has pushed their stocks higher in pre-market. 

“The ‘gang of four,’ Alphabet, Amazon, Apple and Facebook all hit match-winning home runs with the release of their Q2 earnings in after-hours trading. Of the four, only Alphabet suffered a sales drop, and even that was less than expected. The other three showed impressive gains and blew forecasts out of the water,” Jeffrey Halley, Senior Market Analyst for Asia Pacific at OANDA wrote in an email to clients on Thursday. 

Deutsche Bank’s Jim Reid in his morning note, ‘Early Morning Reid’ said the four tech companies represent about 16% of the S&P 500 and over a third of the Nasdaq 100. 

“Apple (+6% after-market trading) reported quarterly revenues ahead of analysts’ estimates as iPhone and laptop demand surged, causing revenues to come in 11% higher than a year earlier,” he wrote.

“Facebook (+6% after-market trading) saw Q2 sales beat even the most bullish analyst’s estimate, with revenues rising 11%. Amazon (+5% after-market trading) beat on profits even after increasing costs substantially through the pandemic. Q2 revenues were up 40% from the same quarter last year, which offset over $4bn in incremental covid-1 related costs. Lastly, Google’s parent company, Alphabet, had falling revenues for the first time as companies lowered ad-spend during the pandemic.”

The unprecedented hacking of celebrity Twitter accounts this month was caused by human error and a spear-phishing attack on Twitter employees, the company has confirmed.

Spear-phishing is a targeted attack designed to trick people into handing out information such as passwords.

Twitter said its staff were targeted through their phones.

The successful attempt let attackers tweet from celebrity accounts and access their private direct messages.

The accounts of Microsoft founder Bill Gates, Democratic presidential hopeful Joe Biden and reality star Kim Kardashian West were compromised, and shared a Bitcoin scam.

It reportedly netted the scammers more than $100,000 (£80,000).

The attack has raised concerns about the level of access that Twitter employees, and subsequently the hackers, have to user accounts.

Twitter acknowledged that concern in its statement, saying that it was “taking a hard look” at how it could improve its permissions and processes.

“Access to these tools is strictly limited and is only granted for valid business reasons,” the company said.

Not all the employees targeted in the spear-phishing attack had access to the in-house tools, Twitter said – but they did have access to the internal network and other systems.

Once the attackers had acquired user credentials to let them inside Twitter’s network, the next stage of their attack was much easier.

They targeted other employees who had access to account controls.

Analysis

By Joe Tidy, cyber-security reporter

Twitter isn’t clarifying whether or not their employees were duped by an email or a phone call. The consensus in the information security community is that it was the latter.

Phonecall spear-phishing, commonly known as vishing, is bread and butter for the sort of hackers who are suspected of this attack.

The criminals obtained the phone numbers of a handful of Twitter staff and, by using friendly persuasion and trickery, got them to hand over usernames and passwords that gave them an initial foothold into the internal system.

• Twitter hack: What went wrong and why it matters
• FBI investigates major Twitter hack

As Twitter puts it, the scammers “exploited human vulnerabilities”. You can imagine how it possibly went:

Hacker to Twitter employee: “Hi, I’m new to the department and I’ve locked myself out of the Twitter internal portal, can you do me a huge favour and give me the login again?”

The fact that Twitter staff were susceptible to these basic attacks is embarrassing for a company built on being at the forefront of digital technology and internet culture.

Twitter said the initial spear-phishing attempt happened on 15 July – the same day the accounts were compromised, suggesting the accounts were accessed within hours.

“This attack relied on a significant and concerted attempt to mislead certain employees and exploit human vulnerabilities to gain access to our internal systems,” the company said.

“This was a striking reminder of how important each person on our team is in protecting our service.”

Twitter did not state whether the attack involved voice calls, despite a previous report from Bloomberg stating that at least one Twitter employee was contacted by attackers through a phone call.

Phishing is most commonly done by email and text message, encouraging recipients to click on links that take them to websites with fake log-in screens.

Spear-phishing is a version of the scam targeted at one person or a specific company, and is usually heavily customised to make it more believable.

One victim whose account was compromised told the BBC there were several things Twitter could have done differently.

“They shouldn’t give the ability to a single employee to remove both email address on file and two-factor authentication,” they said.

“I understand why there’s a need for this – for example if a dormant account has a very old email that’s inaccessible and you’ve lost your phone or something- but it should require two employees to sign off.”

They also said communication from Twitter was poor.

“It took 10 days to reset this account with no actual personal response from Twitter. I literally got a ‘click here to continue’ automated email from their system when they added my email back to the account to allow me to reset it – and it looked like a phishing email.”

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